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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neuropharmacology. 2019 Apr 6;158:107596. doi: 10.1016/j.neuropharm.2019.04.002

Table 5.

Plasma creatinine concentrations after s.c. administration of 1, 3, or 10 μg/kg carfentanil in male rats.

Carfentanil
Dose		 Plasma Creatinine (μmol/L)a
0 30 min 1 h 2 h 4 h 8 h
1 μg/kg 72 ± 8 68 ± 8 78 ± 6 87 ± 7 93 ±11 80 ± 9
3 μg/kg 78 ± 7 69 ± 6 79 ± 8 106 ± 13 125 ± 17 137 ± 44*
10 μg/kg 69 ± 13 86 ± 9 94 ± 12 107 ± 17 147 ± 23 192 ± 31*
a

Creatinine was measured via enzymatic reaction as described in Materials and Methods.

*

= significant difference compared to 1 μg/kg dose (Tukey’s p<0.05)