Table 2.
Associations between SNPs and cognitive performance.
| vMWT Latency | vMWT Distance | TPDT Trials | TPDT Errors | RL Trials | RL Errors | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Statistic | p | Statistic | p | Statistic | p | Statistic | p | Statistic | p | Statistic | p | |
| KIBRA | ||||||||||||
| rs17070145 | F = 1.86 | .16 | F = .71 | .49 | F = 1.41 | .25 | F = .11 | .90 | F = .53 | .59 | F = .52 | .60 |
| rs10475878 | F = 1.38 | .24 | F = .15 | .70 | F = .77 | .38 | F = 1.23 | .27 | F = .62 | .43 | F = .21 | .65 |
| rs4320284 | F = .14 | .87 | F = .24 | .79 | F = 2.07 | .13 | F = .76 | .47 | F = .69 | .51 | F = .35 | .71 |
| rs11740112 | F = 2.81 | .06 | F = 1.15 | .32 | F = .69 | .50 | F = .40 | .67 | F = 1.41 | .25 | F = 2.05 | .13 |
| rs244904 | F = 3.27 | .003 | F = 2.92 | .06 | F = 6.39 | .01 | F = 1.84 | .16 | F = .15 | .86 | F = .12 | .89 |
| rs10040267 | F = .60 | .55 | F = 2.74 | .07 | F = 1.47 | .24 | F = .92 | .40 | F = 1.26 | .29 | F = 1.42 | .25 |
| rs13171394 | F = .14 | .87 | F = .19 | .83 | F = .36 | .70 | F = .43 | .65 | F = 1.03 | .36 | F = 1.81 | .17 |
| rs6555802 | F = 1.81 | .17 | F = .50 | .61 | F = .07 | .93 | F = .29 | .75 | F = 1.69 | .19 | F = 1.72 | .18 |
| rs2241368 | F = .28 | .76 | F = .70 | .50 | F = 2.50 | .09 | F = 3.14 | .05 | F = .89 | .41 | F = .45 | .64 |
| rs1477306 | F = .54 | .59 | F = .48 | .62 | F = 1.29 | .26 | F = .08 | .92 | F = .44 | .64 | F = .38 | .69 |
| rs7700355 | F = .80 | .37 | F = .03 | .87 | F = .40 | .53 | F = .13 | .72 | F < .01 | .99 | F < .01 | .99 |
| rs11750709 | F = .59 | .56 | F = 2.99 | .05 | F = 1.17 | .32 | F = 1.14 | .33 | F = .75 | .48 | F = .52 | .60 |
| rs1422422 | F = 1.13 | .33 | F = 1.67 | .19 | F = 1.80 | .17 | F = 1.69 | .19 | F = .62 | .54 | F = .59 | .56 |
| rs4976592 | F = .01 | .92 | F = .11 | .74 | F = .36 | .55 | F = 1.99 | .16 | F = 1.18 | .28 | F = 1.38 | .24 |
| rs3822660 | F = 1.12 | .29 | F = .70 | .40 | F = 3.08 | .08 | F = 1.52 | .22 | F = .61 | .44 | F = .29 | .59 |
| rs3822659 | F = .39 | .54 | F = 1.23 | .27 | F = 4.19 | .04 | F = 1.61 | .20 | F = 1.66 | .56 | F = 2.15 | .15 |
| rs1030182 | F = 5.02 | .01 | F = 3.18 | .04 | F = .79 | .45 | F = 1.45 | .24 | F = 1.25 | .29 | F = 1.20 | .31 |
| rs7723533 | F = .20 | .65 | F = .09 | .77 | F = .40 | .53 | F = .30 | .59 | F = 1.26 | .56 | F = 1.87 | .17 |
| rs6555791 | F = .14 | .87 | F = .12 | .89 | F = .87 | .42 | F = .66 | .52 | F = 1.19 | .31 | F = 1.29 | .28 |
| rs11134509 | F = .09 | .91 | F = .01 | .99 | F = 1.70 | .19 | F = .46 | .63 | F = .74 | .48 | F = 1.05 | .35 |
| COMT | ||||||||||||
| rs4646316 | F = .04 | .84 | F = .59 | .45 | F = .36 | .55 | F = .03 | .87 | F = 1.74 | .19 | F = 1.84 | .18 |
| rs1544325 | F = .46 | .63 | F = .42 | .66 | F = .11 | .90 | F = .21 | .81 | F = .47 | .63 | F = .66 | .52 |
| rs4680 | F = .04 | .96 | F = .62 | .54 | F = .12 | .88 | F = .77 | .47 | F = .30 | .74 | F = .45 | .64 |
| rs4633 | F = .29 | .75 | F = 1.36 | .26 | F = .44 | .65 | F = .37 | .69 | F = .46 | .63 | F = .35 | .70 |
| rs737865 | F = .23 | .79 | F = .87 | .42 | F = .51 | .60 | F = 1.03 | .36 | F = .44 | .65 | F = .46 | .64 |
| APOE | ||||||||||||
| ε2/ε3/ε4 | F = .34 | .56 | F = .04 | .85 | F = 1.07 | .30 | F = 2.73 | .10 | F = 2.33 | .13 | F = 2.19 | .14 |
| rs157580 | F = .91 | .41 | F = 1.63 | .20 | F = .83 | .36 | F = .22 | .81 | F = 3.16 | .05 | F = 2.85 | .06 |
| rs439401 | F = .14 | .87 | F = .20 | .82 | F = 1.72 | .18 | F = 2.84 | .06 | F = 1.02 | .36 | F = .73 | .48 |
| rs405697 | F = .01 | .94 | F = .29 | .59 | F = 2.12 | .15 | F = .49 | .49 | F = 1.69 | .20 | F = 1.18 | .28 |
| rs157582 | F = 1.45 | .24 | F = .51 | .60 | F = 1.40 | .25 | F = .34 | .71 | F = 1.10 | .34 | F = 1.23 | .30 |
| rs405509 | F = 3.62 | .03 | F = 1.15 | .32 | F = .51 | .60 | F = .69 | .50 | F = .26 | .78 | F = .03 | .98 |
| rs8106922 | F = .48 | .62 | F = .38 | .69 | F = .15 | .86 | F = .08 | .92 | F = .73 | .48 | F = .57 | .57 |
| BDNF | ||||||||||||
| rs1491850 | F = .16 | .85 | F = .84 | .44 | F = 1.39 | .25 | F = 1.65 | .20 | F = .55 | .58 | F = 1.02 | .36 |
| rs985205 | F = 1.26 | .27 | F = .08 | .79 | F = .21 | .65 | F = .70 | .41 | F = 2.00 | .16 | F = 1.98 | .16 |
| rs11030096 | F = .77 | .47 | F = 1.13 | .33 | F = .40 | .67 | F = .83 | .44 | F = 3.00 | .05 | F = 3.14 | .05 |
| rs6265 | F < .01 | .96 | F = 1.03 | .31 | F = .58 | .45 | F = .24 | .63 | F = .57 | .45 | F = .33 | .57 |
| SORL1 | ||||||||||||
| rs668387 | F = .14 | .87 | F = .02 | .98 | F = .34 | .71 | F = 1.35 | .26 | F = .52 | .60 | F = .50 | .61 |
| rs1614735 | F = 1.58 | .21 | F = .45 | .64 | F = .44 | .64 | F = 1.36 | .26 | F = .22 | .80 | F = .25 | .78 |
| rs2282649 | F = 1.42 | .25 | F = 1.93 | .15 | F = .34 | .71 | F = .17 | .84 | F = .35 | .71 | F = .53 | .59 |
| rs1010159 | F = .83 | .44 | F = .54 | .59 | F = 1.59 | .21 | F = .70 | .50 | F = .56 | .57 | F = .52 | .60 |
| rs641120 | F = .05 | .95 | F = .31 | .73 | F = 2.28 | .11 | F = .96 | .39 | F = 2.65 | .08 | F = 2.54 | .08 |
| rs1699102 | F = .09 | .92 | F = .76 | .47 | F = 1.03 | .36 | F = .88 | .42 | F = .62 | .54 | F = .76 | .47 |
| rs3824968 | F = .52 | .60 | F = .55 | .58 | F = 2.03 | .14 | F = .34 | .71 | F = .10 | .91 | F = .10 | .90 |
Note. Only vMWT total latency and distance are included in the table for brevity; other vMWT outcome variables were not significantly associated with SNPs. *Denotes SNPs for which a dominant genetic model was used (minor allele carriers [homozygote or heterozygote] vs. major allele carriers). All other SNPs were analyzed using an additive model.