Extended Data Table 6.
Effective and inhibitory concentrations of the monoclonal antibodies
| SARS-CoV-2 | SARS-CoV-2 | SARS-CoV-2 | SARS-CoV-2 RBD | SARS-CoV RBD | ||
|---|---|---|---|---|---|---|
| Participant ID | Antibody ID | IC50 ng/ml | IC80 ng/ml | IC90 ng/ml | EC50 ng/ml | EC50 ng/ml |
| COV21 | C002 | 8.88 | 21.95 | 37.61 | 3.14 | >1000 |
| COV21 | C003 | 313.79 | 992.62 | >1000 | 6.37 | >1000 |
| COV21 | C004 | 10.67 | 41.08 | 91.71 | 2.39 | >1000 |
| COV21 | C005 | 60.49 | 130.65 | 205.20 | 4.41 | >1000 |
| COV21 | C006 | 321.51 | >1000 | >1000 | 1.81 | >1000 |
| COV21 | C008 | 625.46 | >1000 | >1000 | 4.63 | >1000 |
| COV21 | C009 | 4.82 | 14.54 | 29.34 | 1.80 | >1000 |
| COV21 | C010 | >1000 | >1000 | >1000 | 5.44 | >1000 |
| COV21 | C013 | 42.48 | 360.59 | >1000 | 2.59 | >1000 |
| COV21 | C016 | >1000 | >1000 | >1000 | 7.41 | >1000 |
| COV21 | C017 | 72.67 | 256.18 | 543.87 | 1.63 | >1000 |
| COV21 | C018 | >1000 | >1000 | >1000 | 1.53 | >1000 |
| COV21 | C019 | >1000 | >1000 | >1000 | 11.85 | >1000 |
| COV21 | C021 | >1000 | >1000 | >1000 | 1.25 | >1000 |
| COV21 | C022 | 73.57 | 314.71 | 736.87 | 2.40 | 5.99 |
| COV21 | C027 | >1000 | >1000 | >1000 | 2.65 | 696.05 |
| COV21 | C029 | >1000 | >1000 | >1000 | 4.13 | >1000 |
| COV21 | C030 | >1000 | >1000 | >1000 | 2.89 | >1000 |
| COV21 | C031 | >1000 | >1000 | >1000 | 22.69 | >1000 |
| COV107 | C101 | 8.20 | 30.15 | 65.30 | 1.51 | >1000 |
| COV107 | C102 | 34.03 | 84.21 | 143.23 | 4.54 | >1000 |
| COV107 | C103 | 4.38 | 12.58 | 23.59 | 3.77 | >1000 |
| COV107 | C104 | 23.31 | 72.12 | 140.28 | 8.31 | >1000 |
| COV107 | C105 | 26.09 | 72.24 | 133.70 | 5.20 | >1000 |
| COV107 | C106 | >1000 | >1000 | >1000 | 19.03 | 106.75 |
| COV107 | C107 | >1000 | >1000 | >1000 | 11.55 | >1000 |
| COV107 | C108 | 480.69 | >1000 | >1000 | 5.32 | >1000 |
| COV107 | C110 | 18.44 | 45.11 | 77.28 | 7.29 | >1000 |
| COV107 | C112 | 111.79 | 701.99 | >1000 | 3.38 | >1000 |
| COV107 | C113 | >1000 | >1000 | >1000 | 6.93 | >1000 |
| COV107 | C114 | >1000 | >1000 | >1000 | 9.51 | >1000 |
| COV107 | C115 | 198.33 | 958.18 | >1000 | 3.40 | >1000 |
| COV107 | C116 | >1000 | >1000 | >1000 | 37.56 | >1000 |
| COV107 | C117 | 348.00 | >1000 | >1000 | 5.38 | >1000 |
| COV107 | C118 | 103.69 | 417.76 | >1000 | 3.45 | 3.817 |
| COV107 | C119 | 9.12 | 39.45 | 97.78 | 3.57 | >1000 |
| COV107 | C120 | 13.26 | 26.73 | 40.30 | 1.41 | >1000 |
| COV107 | C121 | 6.73 | 14.31 | 22.33 | 2.85 | >1000 |
| COV107 | C122 | 22.80 | 57.77 | 100.12 | 2.67 | >1000 |
| COV107 | C123 | 149.22 | 355.47 | 595.51 | 1.92 | >1000 |
| COV107 | C124 | 341.82 | 937.26 | >1000 | 2.23 | >1000 |
| COV107 | C125 | 43.32 | 92.54 | 144.26 | 1.87 | >1000 |
| COV107 | C126 | >1000 | >1000 | >1000 | 4.78 | >1000 |
| COV107 | C127 | 68.74 | 190.96 | 347.31 | 2.62 | >1000 |
| COV072 | C128 | 101.22 | 263.35 | 460.73 | 1.95 | >1000 |
| COV072 | C130 | >1000 | >1000 | >1000 | 2.05 | >1000 |
| COV072 | C131 | 30.52 | 178.90 | 759.11 | 1.67 | >1000 |
| COV072 | C132 | 708.67 | >1000 | >1000 | 2.92 | >1000 |
| COV072 | C133 | >1000 | >1000 | >1000 | 1.98 | >1000 |
| COV072 | C134 | >1000 | >1000 | >1000 | 1.57 | >1000 |
| COV072 | C135 | 16.61 | 32.81 | 48.90 | 1.80 | >1000 |
| COV072 | C136 | >1000 | >1000 | >1000 | 33.61 | >1000 |
| COV072 | C137 | >1000 | >1000 | >1000 | 25.22 | >1000 |
| COV072 | C138 | >1000 | >1000 | >1000 | 2.94 | >1000 |
| COV072 | C139 | >1000 | >1000 | >1000 | 1.89 | >1000 |
| COV072 | C140 | 23.88 | 66.24 | 120.69 | 2.19 | >1000 |
| COV072 | C141 | >1000 | >1000 | >1000 | 1.71 | >1000 |
| COV047 | C143 | >1000 | >1000 | >1000 | 3.66 | >1000 |
| COV047 | C144 | 6.91 | 17.28 | 29.66 | 3.24 | >1000 |
| COV047 | C145 | 3.04 | 14.51 | 36.79 | 3.86 | >1000 |
| COV047 | C146 | >1000 | >1000 | >1000 | >1000 | >1000 |
| COV047 | C147 | >1000 | >1000 | >1000 | >1000 | >1000 |
| COV047 | C148 | >1000 | >1000 | >1000 | 64.69 | >1000 |
| COV047 | C150 | >1000 | >1000 | >1000 | 8.11 | >1000 |
| COV047 | C151 | 31.79 | 363.97 | >1000 | 4.30 | >1000 |
| COV047 | C153 | 70.71 | 490.08 | >1000 | 3.17 | >1000 |
| COV047 | C154 | 435.50 | >1000 | >1000 | 2.92 | 10.65 |
| COV047 | C155 | 11.00 | 35.75 | 77.01 | 3.30 | >1000 |
| COV047 | C156 | >1000 | >1000 | >1000 | 3.32 | >1000 |
| COV047 | C164 | 239.15 | 865.40 | >1000 | 2.06 | >1000 |
| COV072 | C165 | 40.81 | 138.66 | 297.38 | 4.25 | >1000 |
| COV96 | C201 | >1000 | >1000 | >1000 | 2.98 | >1000 |
| COV96 | C202 | >1000 | >1000 | >1000 | 3.40 | >1000 |
| COV96 | C204 | >1000 | >1000 | >1000 | 3.73 | 9.41 |
| COV96 | C205 | >1000 | >1000 | >1000 | >1000 | >1000 |
| COV96 | C207 | 158.52 | 960.39 | >1000 | 1.87 | >1000 |
| COV96 | C208 | >1000 | >1000 | >1000 | >1000 | >1000 |
| COV96 | C209 | >1000 | >1000 | >1000 | 3.79 | >1000 |
| COV96 | C210 | 50.73 | 155.24 | 298.90 | 2.83 | >1000 |
| COV96 | C211 | 12.79 | 34.87 | 62.89 | 2.82 | >1000 |
| COV96 | C212 | >1000 | >1000 | >1000 | >1000 | >1000 |
| COV96 | C214 | >1000 | >1000 | >1000 | 5.75 | >1000 |
| COV96 | C215 | >1000 | >1000 | >1000 | 5.33 | 17.944 |
| COV96 | C216 | >1000 | >1000 | >1000 | 9.53 | >1000 |