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[Preprint]. 2020 Jul 5:2020.05.15.098079. [Version 3] doi: 10.1101/2020.05.15.098079

Figure 4. Lung histopathology of infiltrates from mice immunized with different formulations.

Figure 4

Photomicrographs of lung tissue from Balb/c mice to evaluate eosinophil infiltration after challenge with SARS-CoV that had previously been immunized with RBD219-N1 formulated with (A) Alhydrogel® (Al), (B) AddaVax (MF59-like adjuvant), and (C) no adjuvant. (A) Alhydrogel® (Al): Perivascular mononuclear infiltrations (lymphocytes and monocytes/macrophages) along with very few eosinophils, only one seen in this field, indicated by a red arrow. (B) AddaVax (MF59-like adjuvant): Severe inflammatory infiltrations with more than 50% eosinophils, red arrows highlight some of those, and (C) no adjuvant: Inflammatory infiltrations with less than 50% eosinophils. Scale bar = 100 μm.