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[Preprint]. 2020 Jul 5:2020.05.15.098079. [Version 3] doi: 10.1101/2020.05.15.098079

Figure 5. Neutralizing (A) and RBD-specific IgG antibody (B) responses of mice immunized with RBD219-N1/Alhydrogel® (Al) at 1:25 or 1:8 ratios.

Figure 5.

In group 1, a formulation of 0.2 mg/mL RBD in 5 mg/mL Alhydrogel® with the dose of 20 μg/10 μg/10 μg of RBD for prime/1st boost/2nd boost was used for immunization, respectively. In group 2, the formulation 0.2 mg/mL RBD in 1.6mg/mL Alhydrogel® was tested, more specifically, a dosing regimen of 20 μg/10 μg/10 μg RBD for prime/1st boost/2nd boost was used while in group 3, 10 μg RBD were used for all immunizations. Alhydrogel® alone and pre-formulated SARS-S protein (3 μg) were used in groups 4 and 5, respectively, as negative and positive controls