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. 2020 Jun 1;15(6):e0233961. doi: 10.1371/journal.pone.0233961

Table 1. Peptide sequences and their characterizations by SPR (n = 1).

Sequence ka (1/Ms) kd (1/s) KD (M) Competition SPR
%Inhibition Concentration tested (μM)
IL-23R 1.70E+05 1.51E-03 8.92E-09 98.0 0.1
23–652 DTLTKSFCYFGTWCQMYGST 3.66E+04 2.63E-03 7.18E-08 0.4 3
23–644 HVPDPCWFGLLCDVLNS 4.93E+04 1.29E-01 2.62E-06 Not done -
23–437 FTKEIDSWWLSLMSS 1.78E+05 1.86E+00 1.05E-05 57.6% 30
23–441 QKITQCVYIIWTYPCLLNDV 1.90E+05 1.74E-01 9.11E-07 100.0% 30
23–446 GLRERCVRNYGHEFCQNWYW 3.88E+06 8.63E-02 2.23E-08 79.1% 3
23–447 LECLYYLRWKVCDN 4.83E+04 1.33E+00 2.75E-05 78.7% 30
23–443 LLQTLCQMTSDARTCMLWSI - - *NB - -

* NB: not binding. Chemically synthesized peptide did not retain binding as free peptide.