Fig 1. Cerebrospinal fluid levels of neuron-specific enolase in 59 controls and 43 infants with HIE, according to the severity of the encephalopathy.

CSF-NSE levels in the control group were 10.6 (7.7; 12.9). CSF-NSE levels in 20, 12, and 11 infants with severe, moderate, and mild HIE, respectively, were 220.5 ng/ml (120.5; 368.8), 45.5 ng/ml (26, 75.3), and 26 ng/ml (18, 33). No statistically significant differences were found between any of the grades of HIE compared to controls or between any of the grades of HIE (analysis of variance after log-transformation of CSF-NSE values, with Tukey post hoc pairwise analysis); p<0.05. HIE: hypoxic-ischaemic encephalopathy; CSF-NSE: cerebrospinal fluid–neuron specific enolase.