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. 2020 May 22;11(5):e00179. doi: 10.14309/ctg.0000000000000179

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Additional analyses using surgical samples from ICGC. (a) Receptor tyrosine kinase mRNA expression in the ICGC cohort. The right panel shows relatively low expression of 3 genes, which encode molecules targeted by lenvatinib. When log expression is required for 0 FPKM, 0.01 is added as an offset. Each dot is a single case. (b) The FGFR4 protein levels expressed on tumor cells did not correlate with the amount of mRNA expression. Each dot is a single case. (c) Representative images of FGFR4 protein expression in surgically resected specimens (×100 and ×400 magnification). FGFR, fibroblast growth factor receptor; FPKM, fragments per kilobase of transcript per million mapped reads; HCC, hepatocellular carcinoma; ICGC, International Cancer Genome Consortium; IHC, immunohistochemistry; mRNA, messenger RNA.