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. 2020 May 26;11(5):e00178. doi: 10.14309/ctg.0000000000000178

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Decreased cystine-glutamate transporter (xCT) activity in gastric ulcer of H. pylori-infected mice. (a) Photographs of gastric mucosal lesions showed sporadic hemorrhagic spots in gastric mucosa. Hematoxylin-eosin staining showed gastric mucosal damage with dilation and exfoliation of gastric epithelial cells and disruption of mucosal in H. pylori -infected mice with an infiltration of inflammatory cells in the mucosa and submucosa. (b) Decreased expression of xCT mRNA in Hp⁺ group was detected. (c) Immunohistochemical staining for xCT antigen in gastric tissue. (d) Western blot for xCT in gastric tissue. Data are means ± SEM, N = 8–12, *P < 0.05 vs Hp⁻, **P < 0.01 vs Hp⁻. GAPDH, glyceraldehyde phosphate dehydrogenase; Hp, Helicobacter pylori; mRNA, messenger RNA.