Figure 2.

Genetic variants from regulatory and intron regions of MGAT5 (with a minor allele frequency higher than 10%) and the association with severity in patients with UC. Clustering of patients with UC (hierarchical cluster on the upper side) according to SNPs from the promoter and intron regions (hierarchical cluster on the right side). Each SNP is colored according to the genotype: green, homozygous for the frequent allele; yellow, heterozygous; and red, homozygous for the rare allele. The 3 studied SNPs (rs1257220, rs3814022, and rs4953911) are included in the clustering and highlighted in italic. UC disease of each patient is classified according to the severity as mild (always with 5-ASA or with the need of previous corticotherapy, in blue) and severe (need hospitalization, corticodependent, corticoresistant, no responder to immunossupressors, and need biologics or need surgery, in orange), shown in the line above the cluster of patients. Two distinct clinical clusters were created, one comprising 100% of patients with a low severity (highlighted with blue) and the other with 81% of patients with a high severity (highlighted with orange). SNP, single nucleotide polymorphism; UC, ulcerative colitis.