Table 2. Numbers of DEGs and DAS events in different splicing-related factors recovered in the forward genetic screen.
| Differentially Expressed Genes | ||||||
|---|---|---|---|---|---|---|
| Direction of change | cbp80 | coilin a | cwc16a a | smfa | sfmb | |
| Up | 2105 | 334 | 676 | 3121 | 1093 | |
| Down | 567 | 435 | 265 | 1937 | 1299 | |
| Total Number of DEGs | 2672 | 769 | 941 | 5058 | 2392 | |
| Supplemental Table | Table S4 | Table S6 | Table S8 | Table S9 | Table S9 | |
| Differential Alternative Splicing | ||||||
| Event | cbp80 | coilin a | cwc16a a | smfa | sfmb | |
| AA | 168 (8.1) | 129 (44.9) | 45 (14.2) | 292 (13.4) | 69 (19.5) | |
| AD | 199 (9.6) | 17 (5.9) | 27 (8.5) | 244 (11.2) | 37 (10.5) | |
| CE | 158 (7.7) | 20 (7.0) | 20 (6.3) | 307 (14.1) | 29 (8.2) | |
| EI | 83 (4.0) | 13 (4.5) | 26 (8.2) | 158 (7.2) | 37 (10.5) | |
| RI | 1456 (70.5) | 108 (37.6) | 200 (62.9) | 1183 (54.2) | 181 (51.3) | |
| Total Number of DAS events | 2064 (100) | 287 (100) | 318 (100) | 2184 (100) | 353 (100) | |
| Total Number of DAS genes | 1507 | 255 | 240 | 1465 | 287 | |
| Supplemental Table | Table S3 | Table S5 | Table S7 | Table S10 | Table S10 | |
Abbreviations: AA, alternative acceptor/alternative 3′ splice site; AD, alternative donor/alternative 5′ splice site; CE, cassette exon; EI, exitron; RI, retained intron.
a
Only the DEGs/DAS events changed in all alleles, with the same direction of change, are listed here. For the full overview of alternative splicing events per allele, see the respective supplementary tables.