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. 2020 Apr 10;10(6):1843–1852. doi: 10.1534/g3.120.401164

Table 1. List of human genes that suppress FUS toxicity.

Gene Name Short Description
ASB7 Belongs to a family of ankyrin repeat proteins that regulate protein turnover by targeting proteins for polyubiquitin and proteasome-mediated degradation
CDX2 Member of caudal-related homeobox transcription factor family
CPEB1 Binding to the polyadenylation element, and regulating mRNA translation and processing
CPEB2 Regulating translation of target mRNAs by binding to the polyadenylation element in the 3′UTR
CPSF4 Component of the cleavage and polyadenylation specificity factor complex
CPSF6 Subunit of a cleavage factor required for 3′ RNA cleavage and polyadenylation processing
DENND11 Probable guanine nucleotide exchange factor (GEF)
DLX4 Member of Distal-less family of homeobox-containing genes
DUSP10 Protein phosphatase involved in the inactivation of MAP kinases
EBF1 Transcription factor expressed in early B-cells, adipocytes, and olfactory neurons.
EBF3 Member of the transcription factors that are involved in B-cell differentiation, bone development and neurogenesis
HLF Homodimers or heterodimers with other PAR family members to activate transcription
HMG20A Chromatin-associated protein playing a role in neuronal differentiation
HMGB3 Associates with chromatin and binds DNA with a preference to non-canonical DNA structures
HOXC4 Member of homeobox family of genes that play important roles in morphogenesis
HOXD4 Member of homeobox family of genes that play important roles in morphogenesis
INPP5A Membrane-associated type I inositol 1,4,5-trisphosphate 5-phosphatase
IRAK4 Serine/threonine-protein kinase that plays a role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways
NKAPD1 Uncharacterized protein C11orf57
OTX1 Homeodomain-containing transcription factor, playing a role in brain development
PABPC5 Binding to the polyA tail and playing a role in mRNA metabolic processes in the cytoplasm
PLAG1 Proto- oncogene, belongs to the PLAG family of zinc finger transcription factors
POLR2G Subunit of RNA polymerase II, the polymerase responsible for synthesizing mRNA
PYM1 Regulator of the exon junction complex (EJC) as an EJC disassembly factor
RAPGEF4 Guanine nucleotide exchange factor that is activated by binding cAMP
RASA3 Inhibitory regulator of the Ras-c AMP pathway
RBM14 Ribonucleoprotein functioning as a general nuclear coactivator, and an RNA splicing modulator
RGL1 Probable guanine nucleotide exchange factor
SF3A2 A component of the splicing factor SF3A complex involved in pre-mRNA splicing
SNTG1 Member of the syntrophin family, involved in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity
SS18 Component of SWI/SNF chromatin remodeling subcomplex
TAF15 Member of the TET family of RNA-binding proteins
TEX11 Regulator of crossing-over during meiosis
TGIF1 Conserved transcription regulator which binds to retinoid X receptor responsive element
THOC5 Component the TREX complex which specifically associates with spliced mRNA, and which is thought to couple mRNA transcription, processing and nuclear export
UGP2 Essential enzyme that catalyzes the conversion of glucose-1- phosphate to UDP-glucose
ZMYND12 Zinc finger MYND domain-containing protein 12