Table 2. Enriched functions of the human-gene suppressors of FUS toxicity.
| GO terms | GO ID | GO category | Enrichment folds | P value | FDR |
|---|---|---|---|---|---|
| mRNA 3′-UTR binding | GO:0003730 | Molecular function | 15.8 | 1.43E-04 | 4.92E-02 |
| mRNA binding | GO:0003729 | Molecular function | 10.6 | 1.01E-06 | 2.25E-03 |
| DNA-binding transcription activator activity, RNA polymerase II-specific | GO:0001228 | Molecular function | 6.3 | 4.05E-05 | 3.03E-02 |
| DNA-binding transcription activator activity | GO:0001216 | Molecular function | 6.2 | 4.30E-05 | 2.75E-02 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GO:0000977 | Molecular function | 4.4 | 8.05E-05 | 4.51E-02 |
| RNA polymerase II regulatory region DNA binding | GO:0001012 | Molecular function | 4.4 | 8.16E-05 | 4.06E-02 |
| Transcription regulatory region sequence-specific DNA binding | GO:0000976 | Molecular function | 4.1 | 1.31E-04 | 4.87E-02 |
| Double-stranded DNA binding | GO:0003690 | Molecular function | 3.9 | 9.27E-05 | 4.15E-02 |
| DNA-binding transcription factor activity, RNA polymerase II-specific | GO:0000981 | Molecular function | 3.9 | 1.00E-04 | 4.09E-02 |
| DNA-binding transcription factor activity | GO:0003700 | Molecular function | 3.4 | 1.65E-04 | 4.61E-02 |
| Transcription regulator activity | GO:0140110 | Molecular function | 3.2 | 3.60E-05 | 3.23E-02 |
| RNA binding | GO:0003723 | Molecular function | 3.1 | 5.85E-05 | 3.73E-02 |
| Embryonic organ development | GO:0048568 | Biological process | 6.6 | 2.80E-05 | 2.03E-02 |
| Positive regulation of RNA metabolic process | GO:0051254 | Biological process | 3.7 | 6.31E-07 | 4.81E-03 |
| Positive regulation of transcription, DNA-templated | GO:0045893 | Biological process | 3.7 | 3.73E-06 | 5.68E-03 |
| Positive regulation of macromolecule biosynthetic process | GO:0010557 | Biological process | 3.5 | 6.52E-07 | 3.31E-03 |
| positive regulation of nucleic acid-templated transcription | GO:1903508 | Biological process | 3.4 | 7.93E-06 | 9.30E-03 |
| Positive regulation of RNA biosynthetic process | GO:1902680 | Biological process | 3.4 | 8.01E-06 | 8.72E-03 |
| Positive regulation of nucleobase-containing compound metabolic process | GO:0045935 | Biological process | 3.4 | 2.37E-06 | 4.02E-03 |
| Positive regulation of cellular biosynthetic process | GO:0031328 | Biological process | 3.3 | 1.39E-06 | 4.23E-03 |
| Positive regulation of gene expression | GO:0010628 | Biological process | 3.3 | 1.39E-06 | 3.53E-03 |
| Positive regulation of biosynthetic process | GO:0009891 | Biological process | 3.3 | 1.78E-06 | 3.87E-03 |
| Nuclear chromatin | GO:0000790 | Cellular component | 4.2 | 2.01E-05 | 1.29E-02 |
| Nuclear chromosome | GO:0000228 | Cellular component | 4.0 | 6.54E-06 | 1.26E-02 |
| Chromatin | GO:0000785 | Cellular component | 3.6 | 9.32E-05 | 4.50E-02 |
FDR correction < 0.05; Fold of enrichment > 3.