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. 2020 Apr 3;10(6):1853–1867. doi: 10.1534/g3.120.401137

Table 3. Validated hyper-recombination genes from the patch assay and pinning assay screens.

Gene name Description Human ortholog(s)
HTA2 Histone H2A H2A
NUP170 Subunit of inner ring of nuclear pore complex NUP155
CSM1 Nucleolar protein that mediates homolog segregation during meiosis I
YDL162C Dubious open reading frame; overlaps the CDC9 promoter LIG1
MSH6 Protein required for mismatch repair in mitosis and meiosis MSH6
CHL4 Outer kinetochore protein required for chromosome stability CENPN
RNH202 Ribonuclease H2 subunit RNASEH2B
RAD4 Protein that recognizes and binds damaged DNA during NER XPC
YER188W Putative protein of unknown function
DST1 General transcription elongation factor TFIIS TCEA1, TCEA2, TCEA3
RAD6 Ubiquitin-conjugating enzyme UBE2A, UBE2B
RRM3 DNA helicase involved in rDNA replication and Ty1 transposition PIF1
THP2 Subunit of the THO and TREX complexes
SKN7 Nuclear response regulator and transcription factor HSF1, HSF2, HSF4, HSF5
HYR1 Thiol peroxidase GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7
RAD27 5′ to 3′ exonuclease, 5′ flap endonuclease FEN1
APN1 Major apurinic/apyrimidinic endonuclease APE1
RNH203 Ribonuclease H2 subunit RNASEH2C
TOP3 DNA Topoisomerase III TOP3A
YLR235C Dubious open reading frame; overlaps the TOP3 gene TOP3A
YAP1 Basic leucine zipper transcription factor
TSA1 Thioredoxin peroxidase PRDX1, PRDX2, PRDX3, PRDX4
CSM3 Replication fork associated factor TIPIN
MLH1 Protein required for mismatch repair in mitosis and meiosis MLH1
SGS1 RecQ family nucleolar DNA helicase BLM
ABZ2 Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase)
RNH201 Ribonuclease H2 catalytic subunit RNASEH2A
PMS1 ATP-binding protein required for mismatch repair PMS1
MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities WRNIP1
TOF1 Subunit of a replication-pausing checkpoint complex TIMELESS
MSH2 Protein that binds to DNA mismatches MSH2
DFG16 Probable multiple transmembrane protein
ELG1 Subunit of an alternative replication factor C complex ATAD5
RMI1 Subunit of the RecQ (Sgs1) - Topo III (Top3) complex RMI1
VMA11 Vacuolar ATPase V0 domain subunit c’ ATP6VOC