Table 1.

Summary of the included SAPALDIA sample.

	SAPALDIA2a	SAPALDIA3a
Categorical variables [n (%)]	1,170 (100)	1,372 (100)
Women	623 (53)	737 (54)
Formal education (y)
$\le 9$	56 (5)	62 (4)
10–12	759 (65)	887 (65)
$>12$	355 (30)	423 (31)
Smoking status
Never	539 (46)	659 (48)
Former	355 (30)	496 (36)
Current	276 (24)	217 (16)
Passive smoke exposure	289 (25)	159 (12)
Alcohol intake $>1\text{\hspace{0.17em}glass}/\mathrm{d}$	456 (39)	529 (38)
Fruit intake $\le 3\mathrm{d}/\mathrm{wk}$	326 (28)	280 (20)
Vegetable intake $\le 3\mathrm{d}/\mathrm{wk}$	86 (7)	100 (7)
Urban area	689 (59)	897 (60)
Prevalent asthma	161 (14)	398 (21)
$\text{MVPA}<150\text{\hspace{0.17em}min}/\mathrm{wk}$	330 (28)	354 (26)
Regular nighttime opening of windows	971 (83)	1,131 (82)
Nested study
ALEC	972 (83)	970 (71)
EXPOsOMICS	198 (17)	402 (29)
Continuous variables [median (IQR)]
Age	50 (18)	58 (18)
Body mass index ($\mathrm{kg}/{\mathrm{m}}^2$)	24.9 (5)	25.8 (6)
Smoking pack-years	0.4 (15)	0 (14)
Neighborhood index of socioeconomic position (%)	64.6 (13)	64.8 (13)
Greenness index within 1-km buffer	0.61 (0.2)	0.62 (0.2)
Aircraft Lnight (dB)	20 (2)	20.1 (5)
Railway Lnight (dB)	22.9 (14)	20 (10)
Road traffic Lnight (dB)	44.9 (111)	45.1 (11)
Aircraft Lden (dB)	30 (9)	32.7 (8)
Railway Lden (dB)	30 (11)	30 (7)
Road traffic Lden (dB)	53.7 (11)	53.9 (11)
${\mathrm{NO}}_2$ ($\mathrm{\mu }\mathrm{g}/{\mathrm{m}}^3$)	20.2 (14)	16.7 (10)
${\mathrm{PM}}_{2.5}$ ($\mathrm{\mu }\mathrm{g}/{\mathrm{m}}^3$)	14.3 (5)	12.9 (2)

Note: ALEC and EXPOsOMICS are European cohort consortia in which SAPALDIA participates. ALEC, Aging Lungs in European Cohorts; MVPA, moderate to vigorous physical activity; ${\mathrm{PM}}_{2.5}$, particulate matter with aerodynamic diameter $<2.5\mathrm{\mu }\mathrm{m}$; ${\mathrm{NO}}_2$, nitrogen dioxide; SAPALDIA, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults.

^aPopulation included in the analysis was limited to participants with complete methylome, exposure, and covariate data.