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Sequence comparison around hotspot residues for proteases of four types of viruses.
| Virus Protease | PDB Code | Residue ID of Hot Spots (colored in red) | ||||
|---|---|---|---|---|---|---|
| 41 | 49 | 142 | 164–166 | 189 | ||
| COVID-19 | 6LU7 | CPRHVIC | SEDMLNP | FLNGSC | CYMHHMELP | VDRQTAQ |
| SARS | 3TNT | CPRHVIC | AEDMLNP | FLNGSC | CYMHHMELP | VDRQTAQ |
| MERS | 5WKK | CPRHVMC | ADQLSDP | FLCGSC | CYMHQMELA | MDKQVHQ |
| HCV NS3/4A | 3M5L | TVYHGAG | ––––––– | YLKGSA | VGIFRAAVS | ––––––– |
