Table 3.
HIV-1 Protease Inhibitor Drugs
| Inhibitor (Trade Name ; Manufacturer) | Identifier of Protease Inhibitor | Database ID of Protease Inhibitor Structurea | AutoDock Score (kcal/mol) Lowest “Energy” | Drug Status |
|---|---|---|---|---|
| HIV-1 Protease Inhibitor Drugs | ||||
| Nelfinavir (Viracept; Agouron / Lilly / Roche / ViiV Healthcare) | NFV | 3EKX | −8.83 | Prescription Drug |
| Saquinavir (Invirase / Fortovase; Roche) | SQV | 3OXC | −8.67 | Prescription Drug |
| Indinavir (Crixivan; Merck) | IDV | 2R5P | −8.39 | Investigational |
| Ritonavir (Norvir / Kaletrab; AbbVie) | RTV | 2B60 | −7.92 | Prescription Drug |
| Darunavir (Prezista; Tibotec / Janssen) | DRV | 4LL3 | −7.47 | Prescription Drug |
| Tipranavir (Aptivus; Boehringer Ingelheim) | TPV | 6DIF | −7.34 | Prescription Drug |
| Atazanavir Reyataz / Evotaz; Bristol-Myers Squibb | ATA | 2AQU | −7.04 | Prescription Drug |
| Lopinavir (Kaletrab; AbbVie) | LOP | 1MUI | −6.71 | Prescription Drug |
| Amprenavir (Agenerase, GlaxoSmithKline) | 478 | 3EKV | −6.58 | Prescription Drug |
(a)
Atomic coordinates for the inhibitor were taken from the PDB coordinates of the corresponding complex of the inhibitor bound to HCV 3C/4A protease.
(b)
Kaletra is a formulation including both lopinavir and ritonavir protease inhibitors.