Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic outline of the hypothalamic MC4R pathway with POMC, PCSK1, LEPR, Leptin (LEP), and the MC4R as critical mediators of appetite, energy expenditure, and body weight. Red crosses on each gene indicate that genetic evidence is available linking a genetic deficiency in each gene with severe early-onset childhood obesity and hyperphagia.
