Table 1.

Grouping of MC4R Pathway Variants

Category	Gene Source	POMC	PSCK1	LEPR	Total
Group 1	Literature	30	31	22	83
	Novel (nonsense, splice site, frameshift)	20	24	39	83
Group 2	Computationally predicted high-impact missense	85	176	160	421
Total		135	231	221	587