Figure 1.

Illustration of False Positive and CAD Detection Rates for CAD Polygenic Scores

Shown are distributions of polygenic scores for people with coronary artery disease (CAD) (solid line) and controls (dashed line). The vertical line indicates a possible polygenic score cutoff for predictive testing (at scores giving a false positive rate of 5%, in this drawing). The false positive rate is the proportion of control individuals with positive scores = dark gray/[dark gray + light gray + blue]. The detection rate is the proportion of patients with CAD with positive scores = [orange + dark gray]/[orange + dark gray + yellow + light gray]. The CAD detection rate is low at the cutoff used. The false positive rate will be higher for scores with higher detection rates. The figure was adapted from Supplemental Figure 1 (all ancestries; normalized score; Partners Healthcare Biobank) in Aragam et al. (1).