Table 2. Ratios of resistant cells as calculated by application of the binomial distribution and experimental observations.
| Total number of sample reads (number of trials) | Number of D94G SNPs detected (number of success) p=r | Ratio of resistant cells to sensitive cells (probability of trial success) | 95% Confidence interval [Low]-[High] |
|---|---|---|---|
| 62 | 9 | 0.09–0.24 | [2, 9 - 9, 21] |
| Total number of colonies picked (number of trials) | Number of resistant colonies (number of success) p=r | ||
| 96 | 33 | 0.28–0.44 | [17,33 - 33,61] |
| One or two cells contribute to colony p=1-(1 r)2 | 0.14–0.26 | [17,33 - 33,61] | |
| Total number of colonies tracked | Number that fit resistance criterion | Ratio of resistant cells to sensitive cells | |
| 963 | 237 | 0.2461 | |
| 473 | 114 | 0.2410 | |
| 1476 | 273 | 0.1850 | |
| 1043 | 244 | 0.2339 | |
| 359 | 101 | 0.2557 | |
| 561 | 157 | 0.2799 | |
| 573 | 146 | 0.2548 | |
| 459 | 123 | 0.2680 | |
| Mean resistance ratio | 0.2456 |