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. 2020 May 26;13:4665–4678. doi: 10.2147/OTT.S245681

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© 2020 Yang et al.

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FAM83D depletion inhibits growth in vitro and in vivo and increases of esophageal carcinoma cell apoptosis and radiosensitivity. (A) Downregulation of FAM83D expression with FAM83D shRNA significantly inhibited the growth of ECA109 and KYSE30 cells after irradiation. (B) Survival curves of cells treated with IR were drawn. GraphPad Prism 5.0 was used to fit cell survival curves, as well as the radiation biological parameters. Cells in the control and NC groups had a broader distribution than cells in the FAM83D shRNA group, indicating that they were more radioresistant than the latter. (C) The nude mice were sacrificed, and the tumors were dissected. The data are shown as the mean ± standard error for each group (n=5). (D) The apoptosis rates in the three groups were significantly higher after irradiation than before. In addition, apoptosis was obviously induced after silencing FAM83D in ECA109 cells. (E) Similar results were observed in KYSE30 cells. *P<0.05, **P<0.01 compared with the control group and NC group. ^▲▲P<0.01 compared with the corresponding unirradiated group.