Figure 3.

Design considerations of triagonists. (a) Each receptor (GLP-1R, blue; GCGR, red; GIPR, green) responds to its respective ligand. (b) A balanced fusion structure uses each individual peptide to provide recognition at all receptors. (c) A balanced hybrid peptide is a sequence-hybridized molecule of comparable size to the native peptides with equipotent activities at all receptors. (d) An unbalanced hybrid peptide is a sequence-intermixed molecule that preferentially activates certain receptors with higher affinity than others.