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. 2020 May 27;13:4779–4790. doi: 10.2147/OTT.S250028

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© 2020 Wang et al.

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ZNRD1-AS1 was the direct target of miR-335. (A) ZNRD1-AS1 knockdown significantly increased miR-335 expression. (B) MiR-335 overexpression repressed ZNRD1-AS1 expression. (C) Sequence alignment of miR-335 binding sites within the 3′-UTR of ZNRD1-AS1. (D) Luciferase reporter assays revealed that miR-335 overexpression represses the luciferase activity of the wild-type ZNRD1-AS1 3ʹUTR compared with that of the mutant. (E) RIP assays indicated that ZNRD1-AS1 and miR-335 are similarly enriched in beads containing anti-Ago2 antibody. **p < 0.01.