Table 1.
Characteristic | All | AL | ASAQ | ASMQ | DP | AAP | AS | ASSP | Q | QC | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
N | % (N) Mean (SD) |
|
EGA (week) | 4334 | 24.6 (5.7) | 1087 | 24.3 (5.7) | 775 | 24.1 (5.1) | 965 | 25.3 (5.3) | 837 | 24.4 (5.7) | 81 | 26.2 (7.1) | 193 | 26.6 (7.4) | 154 | 24.4 (5.8) | 184 | 23.8 (6.3) | 58 | 26.8 (6.5) |
Age group <20 | 4334 | 32.0 (1388) | 1087 | 36.5 (397) | 775 | 31.7 (246) | 965 | 28.1 (271) | 837 | 39.8 (333) | 81 | 28.4 (23) | 193 | 19.2 (37) | 154 | 20.1 (31) | 184 | 20.7 (38) | 58 | 20.7 (12) |
20–24 | 32.3 (1399) | 31.1 (338) | 31.6 (245) | 33.6 (324) | 30.0 (251) | 27.2 (22) | 24.9 (48) | 55.2 (85) | 39.7 (73) | 22.4 (13) | ||||||||||
25–29 | 19.3 (836) | 17.8 (194) | 20.1 (156) | 21.2 (205) | 16.6 (139) | 22.2 (18) | 21.2 (41) | 17.5 (27) | 20.1 (37) | 32.8 (19) | ||||||||||
30–34 | 9.7 (419) | 8.1 (88) | 10.7 (83) | 10.6 (102) | 8.4 (70) | 13.6 (11) | 14.5 (28) | 3.9 (6) | 13.0 (24) | 12.1 (7) | ||||||||||
>35 (years) | 6.7 (292) | 6.4 (70) | 5.8 (45) | 6.5 (63) | 5.3 (44) | 8.6 (7) | 20.2 (39) | 3.2 (5) | 6.5 (12) | 12.1 (7) | ||||||||||
Gravidity 1 | 4297 | 35.4 (1519) | 1053 | 35.1 (370) | 774 | 36.4 (282) | 965 | 33.2 (320) | 837 | 38.4 (321) | 81 | 29.6 (24) | 193 | 27.5 (53) | 154 | 48.7 (75) | 182 | 32.4 (59) | 58 | 25.9 (15) |
2 | 23.4 (1005) | 23.2 (244) | 22.5 (174) | 24.1 (233) | 24.9 (208) | 21.0 (17) | 15.0 (29) | 24.7 (38) | 25.8 (47) | 25.9 (15) | ||||||||||
≥3 | 41.3 (1773) | 41.7 (439) | 41.1 (318) | 42.7 (412) | 36.8 (308) | 49.4 (40) | 57.5 (111) | 26.6 (41) | 41.8 (76) | 48.3 (28) | ||||||||||
Parity 0 | 4329 | 42.7 (1847) | 1083 | 42.6 (461) | 774 | 41.1 (318) | 965 | 42.6 (411) | 837 | 47.6 (398) | 81 | 33.3 (27) | 193 | 30.1 (58) | 154 | 56.5 (87) | 184 | 37.0 (68) | 58 | 32.8 (19) |
1 | 21.8 (945) | 20.9 (226) | 22.4 (173) | 20.9 (202) | 22.6 (189) | 24.7 (20) | 19.7 (38) | 23.4 (36) | 25.0 (46) | 25.9 (15) | ||||||||||
≥2 | 35.5 (1537) | 36.6 (396) | 36.6 (283) | 36.5 (352) | 29.9 (250) | 42.0 (34) | 50.3 (97) | 20.1 (31) | 38.0 (70) | 41.4 (24) | ||||||||||
Height (cm) | 3809 | 155.8 (6.9) | 934 | 156.1 (6.6) | 775 | 157.9 (6.5) | 927 | 156.1 (7.3) | 837 | 155.3 (6.3) | 33 | 150.2 (8.3) | 136 | 151.7 (5.6) | 118 | 150.0 (7.0) | 49 | 153.3 (5.1) | 0 | |
Weight (kg) | 4333 | 53.9 (8.3) | 1086 | 53.7 (7.4) | 775 | 56.3 (8.8) | 965 | 54.0 (8.5) | 837 | 54.4 (8.2) | 81 | 49.8 (6.6) | 193 | 49.5 (6.4) | 154 | 47.8 (6.9) | 184 | 55.2 (9.4) | 58 | 49.8 (5.5) |
BMI <18.5 | 3809 | 6.3 (239) | 934 | 5.8 (54) | 775 | 4.9 (38) | 927 | 6.8 (63) | 837 | 5.5 (46) | 33 | 6.1 (2) | 136 | 8.1 (11) | 118 | 18.6 (22) | 49 | 6.1 (3) | 0 | |
18.5–24.9 | 79.9 (3044) | 84.7 (791) | 78.8 (611) | 77.9 (722) | 77.8 (651) | 78.8 (26) | 83.8 (114) | 72.0 (85) | 89.8 (44) | |||||||||||
25.0–29.9 | 12.0 (458) | 8.9 (83) | 12.4 (96) | 13.4 (124) | 15.4 (129) | 9.1 (3) | 7.4 (10) | 9.3 (11) | 4.1 (2) | |||||||||||
≥30 (kg/m2) | 1.8 (68) | 0.6 (6) | 3.9 (30) | 1.9 (18) | 1.3 (11) | 6.1 (2) | 0.7 (1) | 0.0 (0) | 0.0 (0) | |||||||||||
Fever (temperature >37.5°C) | 4292 | 9.2 (395) | 1086 | 8.2 (89) | 775 | 4.8 (37) | 964 | 9.8 (94) | 834 | 4.2 (35) | 81 | 24.7 (20) | 193 | 25.4 (49) | 117 | 24.8 (29) | 184 | 16.8 (31) | 58 | 19.0 (11) |
Haemoglobin on day 0 (g/dL) | 4308 | 10.0 (1.4) | 1075 | 10.2 (1.4) | 775 | 10.0 (1.3) | 963 | 9.9 (1.4) | 834 | 10.0 (1.4) | 80 | 9.4 (1.5) | 193 | 9.5 (1.5) | 152 | 9.3 (1.4) | 179 | 10.2 (1.8) | 57 | 9.1 (1.6) |
Parasitaemia (log10/μL) | 4334 | 3.0 (0.9) | 1087 | 3.1 (0.8) | 775 | 2.8 (0.8) | 965 | 3.0 (0.8) | 837 | 2.9 (0.8) | 81 | 3.6 (1.1) | 193 | 3.3 (1.0) | 154 | 3.4 (0.8) | 184 | 3.4 (0.9) | 58 | 3.3 (1.1) |
Presence of gametocytes | 4271 | 3.8 (161) | 1083 | 3.9 (42) | 775 | 3.0 (23) | 946 | 1.7 (16) | 837 | 3.8 (32) | 81 | 3.7 (3) | 189 | 10.1 (19) | 118 | 3.4 (4) | 184 | 9.2 (17) | 58 | 8.6 (5) |
Mixed infection | 4334 | 0.7 (32) | 1087 | 0.9 (10) | 775 | 0.0 (0) | 965 | 0.0 (0) | 837 | 0.7 (6) | 81 | 1.2 (1) | 193 | 6.2 (12) | 154 | 0.0 (0) | 184 | 0.0 (0) | 58 | 5.2 (3) |
HIV infection | 2730 | 1.3 (35) | 808 | 1.4 (11) | 573 | 0.5 (3) | 570 | 0.2 (1) | 668 | 0.9 (6) | 0 | 0 | 27 | 22.2 (6) | 84 | 9.5 (8) | 0 |
AAP artesunate with atovaquone-proguanil, AL artemether-lumefantrine, AS artesunate monotherapy, ASAQ artesunate-amodiaquine, ASMQ artesunate-mefloquine, ASSP artesunate-sulfadoxine-pyrimethamine, BMI body mass index, DP dihydroartemisinin-piperaquine, EGA estimated gestational age, HIV human immunodeficiency virus, Q quinine monotherapy, QC quinine with clindamycin, SD standard deviation