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. Author manuscript; available in PMC: 2021 Mar 17.
Published in final edited form as: Acc Chem Res. 2020 Mar 5;53(3):654–661. doi: 10.1021/acs.accounts.9b00613

Figure 1.

Figure 1.

Illustration of common structural changes associated with cryptic binding site formation. a. Side chain rearrangements as shown in IL2 (apo: 1M47_A, holo: 1PY2_D), b. loop movements in NPC2 (apo: 1NEP_A, holo: 2HKA_C), c. secondary structure changes like the partial helix unfolding in LfrR (apo: 2WGB_A, holo: 2V57_A), and d. interdomain motions in EF-TU (apo: 1EXM_A, holo: 1HA3_B). Apo structures are show in gray and holo structures in slate blue, while red arrows highlight the main structural changes.