Table 4. Coefficients and LOO cross-validation parameters of allometric models describing selected pharmacokinetic parameters of tylosin A in turkeys of four different body weights (pooled).

Parameters		ClB	Vdss	T1/2el
Allometric models for PK parameters
	Unit	l/h	l	h
	N	38	38	38
	Coefficient	4.179	0.541	0.776
	Exponent	0.575	0.815	0.481
	R2	0.775	0.687	0.551
	F	71.37	39.77	27.35
	P	< 0.01	< 0.01	< 0.01
LOO cross-validation parameters
	R2	0.665	0.525	0.432
	Q2	0.614	0.466	0.338
	Q2 − R2	0.051	0.032	0.094
	Q2asym	0.646	0.499	0.338
	Q2asym − Q2	0.032	0.032	0.062
	SS	2,218.71	312.58	60.33
	PRESS	856.40	166.79	39.93
	Validation outcome	-	-	-

F and P determined by linear regression analysis of observed vs. predicted values. For validation outcome, “-” denotes that model does not meet all validation criteria.

LOO, leave-one-out; Cl_B, body clearance; Vd_ss, volume of distribution at steady state; T_1/2el, elimination half-life; N, number of individual parameters used to develop the model; SS, sum of squares; PRESS, predicted residual error sum of squares; Q²_asym, Q² asymptotic.