Table 3. Phenotypes and minimum inhibitory concentrations of 17 high-level mupirocin-resistant strains.
| Strains No. | Bacterial species | Phenotypes* | Antimicrobial and antiseptic agent/MIC breakpoints (ug/mL) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coagulase | Mannitol | MUP/≥ 256 | PEN/≥ 0.25 | CIP/≥ 4 | FOX/≥ 8 | ERY/≥ 8 | TMP/≥ 16 | SMX/≥ 512 | TET/≥ 16 | CLI/≥ 4 | FUS/≥ 4 | GEN/≥ 16 | CHL/≥ 32 | SYN/≥ 4 | CHH | ||
| 17-1 | Staphylococcus haemolyticus | − | − | ≥ 256 | ≥ 2 | 8 | ≥ 16 | 4 | 8 | ≥ 512 | 2 | < 0.12 | ≥ 4 | ≥ 16 | < 4 | < 0.5 | 2 |
| 17-26 | Staphylococcus haemolyticus | − | − | ≥ 256 | ≥ 2 | ≥ 8 | ≥ 16 | ≥ 8 | 4 | ≥ 512 | ≥ 16 | ≥ 4 | < 0.5 | ≥ 16 | 8 | 1 | 16 |
| 17-71 | Staphylococcus epidermidis | − | − | ≥ 256 | > 2 | 8 | 8 | ≥ 8 | < 2 | 256 | < 0.5 | < 0.12 | ≥ 4 | 4 | < 4 | < 0.5 | 4 |
| 17-76 | Corynebacterium auriscanis | − | − | ≥ 256 | ≥ 2 | 4 | 16 | ≥ 8 | ≥ 32 | ≥ 512 | 8 | ≥ 4 | < 0.5 | 16 | < 4 | < 0.5 | - |
| 17-80 | Corynebacterium auriscanis | − | − | ≥ 256 | ≥ 2 | ≥ 8 | 16 | < 0.25 | ≥ 32 | ≥ 512 | < 0.5 | < 0.12 | < 0.5 | 16 | 32 | < 0.5 | - |
| 17-109 | Corynebacterium auriscanis | − | − | ≥ 256 | 0.5 | 4 | 8 | < 0.25 | ≥ 32 | 512 | 1 | 0.5 | < 0.5 | 4 | 8 | < 0.5 | - |
| 17-147 | Staphylococcus epidermidis | − | − | ≥ 256 | 1 | < 0.25 | 4 | ≥ 8 | ≥ 32 | 128 | ≥ 16 | < 0.12 | ≥ 4 | 16 | < 4 | < 0.5 | 2 |
| 18-325 | Staphylococcus warneri | − | + | ≥ 256 | 2 | 0.5 | 8 | < 0.25 | < 2 | 128 | < 0.5 | < 0.12 | ≥ 4 | ≥ 16 | < 4 | 1 | 8 |
| 19-2 | Staphylococcus intermedius | − | − | ≥ 256 | ≥ 2 | 2 | 8 | < 0.25 | < 2 | 128 | > 16 | < 0.12 | ≥ 4 | 4 | < 4 | < 0.5 | 1 |
| 19-181 | Staphylococcus pseudintermedius | − | − | ≥ 256 | > 2 | 1 | 4 | ≥ 8 | ≥ 32 | ≥ 512 | > 16 | ≥ 4 | < 0.5 | 8 | 8 | 4 | 2 |
| 19-525 | Staphylococcus haemolyticus | − | + | ≥ 256 | ≥ 2 | ≥ 8 | ≥ 16 | ≥ 8 | 8 | 128 | 1 | < 0.12 | ≥ 4 | 8 | < 4 | < 0.5 | 8 |
| 19-805 | Staphylococcus cohnii | − | + | ≥ 256 | ≥ 2 | 4 | 4 | ≥ 8 | ≥ 32 | 256 | ≥ 16 | ≥ 4 | < 0.5 | 8 | 64 | < 0.5 | 1 |
| 19-816 | Staphylococcus pseudintermedius | + | − | ≥ 256 | ≥ 2 | 4 | 4 | ≥ 8 | ≥ 32 | 256 | ≥ 16 | ≥ 4 | < 0.5 | 8 | 64 | < 0.5 | 2 |
| 19-850 | Staphylococcus haemolyticus | − | − | ≥ 256 | ≥ 2 | ≥ 8 | 8 | ≥ 8 | ≥ 32 | 512 | ≥ 16 | 0.5 | < 0.5 | 4 | 8 | < 0.5 | 2 |
| 19-877 | Staphylococcus pseudintermedius | + | − | ≥ 256 | ≥ 2 | ≥ 8 | 4 | ≥ 8 | ≥ 32 | 256 | ≥ 16 | 0.25 | < 0.5 | 8 | 8 | < 0.5 | 2 |
| 19-878 | Staphylococcus haemolyticus | − | − | ≥ 256 | ≥ 2 | ≥ 8 | ≥ 16 | 4 | ≥ 32 | ≥ 512 | 2 | ≥ 4 | < 0.5 | ≥ 16 | < 4 | 2 | 4 |
| 19-902 | Staphylococcus epidermidis | − | − | ≥ 256 | ≥ 2 | < 0.25 | 16 | < 0.25 | < 2 | 512 | ≥ 16 | < 0.12 | < 0.5 | ≥ 16 | < 4 | < 0.5 | 2 |
| No. (%) of resistant strains | 17 (100) | 17 (100) | 13 (70.6) | 12 (70.6) | 10 (58.8) | 10 (58.8) | 9 (52.9) | 9 (52.9) | 6 (35.3) | 6 (35.3) | 5 (29.4) | 3 (17.6) | 1 (5.9) | NA† | |||
MUP, mupirocin; PEN, penicillin; CIP, ciprofloxacin; FOX, cefoxitin; ERY, erythromycin; TMP, trimethoprim; SMX, sulfamethoxazole; TET, tetracycline; CLI, clindamycin; FUS, fusidate; GEN, gentamicin; CHL, chloramphenicol; SYN, quinupristin-dalfopristin; CHH, chlorhexidine.
*Coagulase and mannitol fermentation: positive (+), negative (−); †NA, not available, because the breakpoint has not yet been established in the Clinical and Laboratory Standards Institute.