Table 3.
Logistic Regression Analysis of Risk Factors on ALNR
| Parameters | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Gender (Female vs male) | 1.226 | 0.613–1.226 | 0.564 | – | – | – |
| Age (years) | 0.987 | 0.952–1.023 | 0.463 | – | – | – |
| Location | ||||||
| (Middle vs upper) | 2.322 | 0.525–10.264 | 0.266 | 0.975 | 0.185–5.143 | 0.976 |
| (Lower vs upper) | 6.618 | 1.456–30.074 | 0.014 | 2.381 | 0.435–13.018 | 0.317 |
| Length (cm) | 1.086 | 0.899–1.312 | 0.394 | – | – | – |
| Width (cm) | 1.399 | 1.075–1.820 | 0.013 | 1.180 | 0.823–1.692 | 0.367 |
| T stage (T1/T2/T3/4a) | 1.852 | 1.090–3.146 | 0.023 | 1.584 | 0.631–3.978 | 0.327 |
| N stage (N0/N1/N2/N3) | 3.911 | 2.664–5.743 | <0.001 | 2.004 | 0.700–5.734 | 0.195 |
| TNM stage (Ⅱa/Ⅱb/Ⅲa/Ⅲb/Ⅳa) | 2.335 | 1.804–3.021 | <0.001 | 0.693 | 0.312–1.538 | 0.367 |
| Differentiation (Well/moderate/poor) | 0.735 | 0.440–1.226 | 0.238 | – | – | – |
| Operation method | ||||||
| (LT vs TLC) | 1.027 | 0.564–1.872 | 0.930 | – | – | – |
| (RT vs TLC) | 0.963 | 0.420–2.207 | 0.929 | – | – | – |
| (Other vs.TLC) | – | – | – | – | – | – |
| Number of resected LNs | 0.991 | 0.962–1.022 | 0.584 | – | – | – |
| Ratio of LNM | 301.618 | 47.720–1906.377 | <0.001 | 1.899 | 0.095–37.805 | 0.674 |
| Lymphadenectomy (Three vs two fields) | 1.245 | 0.332–4.664 | 0.745 | – | – | – |
| Vessel carcinoma embolus (Yes vs no) | 3.213 | 1.409–7.324 | 0.006 | 2.900 | 0.974–8.638 | 0.056 |
| Cancerous node (Yes vs no) | 3.112 | 1.135–8.532 | 0.027 | 0.712 | 0.197–2.574 | 0.604 |
| Regional LNs | ||||||
| UM (Positive vs negative) | 1.947 | 0.805–4.708 | 0.139 | – | – | – |
| MLM (Positive vs negative) | 3.305 | 1.811–6.031 | <0.001 | 1.662 | 0.614–4.501 | 0.318 |
| AR (Positive vs negative) | 12.900 | 6.840–24.329 | <0.001 | 7.499 | 2.522–22.297 | <0.001 |
| Resected number of AR | 1.032 | 0.976–1.091 | 0.273 | – | – | – |
| Ratio of LNM in AR | 127.684 | 28.529–571.461 | <0.001 | 2.215 | 0.284–15.895 | 0.463 |
Note: Bold text indicates a statistical significant (P < 0.05).
Abbreviations: AR, abdominal region; ALNR, abdominal lymph node recurrence; CI, confidence interval; LNs, lymph nodes; LNM, lymph node metastasis; LT, left transthoracic esophagectomy; MLM, middle and lower mediastinum; N, node; OR, odds ratio; RT, right transthoracic esophagectomy; T, tumor; TLC, thoracoscopy and laparoscopic combined esophagectomy; TNM, tumor-node-metastasis; UM, upper mediastinum.