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NOSH-aspirin induces ROS, iNOS, and p53 and inhibits FoxM1 in vivo. Stored tumors were sectioned, probed, and scored as described in Section 2.8–10. NOSH-aspirin-treatment increased peroxide and super oxide anions, as well as iNOS and p53 expression while it reduced FoxM1 levels. Five different representative fields were used for quantification from each tumor (N=5), in all cases P < 0.01 compared to vehicle treated mice. The scale bar represents 200 μm.
