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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Biochem Pharmacol. 2020 Jan 21;176:113819. doi: 10.1016/j.bcp.2020.113819

Figure 3. Mechanisms of hydrogen sulfide-inhibited insulin secretion from pancreatic β-cell.

Figure 3.

Hydrogen sulfide (H2S) inhibits insulin secretion by opening of KATP channels via Ssulfhydration. Opening of KATP channels causes membrane hyperpolarization and therefore closing of VDCC. H2S also inhibits VDCC directly via S-sulfhydration. H2S inhibits glucose-induced mitochondrial membrane hyperpolarization and ATP production. G6P, Glucose 6-phosphate; SNAP 23/25, Synaptosome Associated Protein 23/25; VAMP, Vesicle Associated Membrane Protein.