Table 4.

Significant Hierarchical Regression Models Predicting ROI Difference Scores from Session 1 to Session 2 by ROI and DTI Scalar

Fornix

FA

RD

Model

F

r^2

β

ΔR^2

F

r^2

β

ΔR^2

Step 1:

0.52

0.08

Gender

0.00938

0.06862

0.00725

−0.08556

Lifetime Alcohol Exposure

0.02276

0.01339

0.00001

−0.00302

Lifetime Drug Use

0.02205

0.16834

0.00000

0.00048

Step 2:

2.16

0.1909 ϯ

1.12

0.1306 ϯ

S2 Number of Birthday Drinks

0.18844

0.53374 ϯ

0.13384

-0.44982 ϯ

Anterior Fornix

FA

RD

MD

Model

F

r^2

β

ΔR^2

F

r^2

β

ΔR^2

F

r^2

β

ΔR^2

Step 1:

0.29

0.29

0.60

Gender

0.00012

−0.04764

0.00000

0.03765

0.00050

0.01131

Lifetime Alcohol Exposure

0.00231

−0.02556

0.01856

0.17892

0.04997

0.23939

Lifetime Drug Use

0.02229

0.17163

0.00735

−0.09718

0.00087

−0.03348

Step 2:

1.97

0.1941 ϯ

2.81 ϯ

0.2603 ϯ

2.52

0.2137 ϯ

S2 Number of Birthday Drinks

0.14445

0.46730 ϯ

0.23172

-0.59186 ϯ

0.19931

-0.54892 ϯ

Posterior Fornix

FA

Model

F

r^2

β

ΔR^2

Step 1:

0.52

Gender

0.01426

0.09610

Lifetime Alcohol Exposure

0.01386

0.05420

Lifetime Drug Use

0.01735

0.14933

Step 2:

1.45

0.1261 ϯ

S2 Number of Birthday Drinks

0.1284

0.44058 ϯ

Corpus Callosum - Splenium

AD

MD

Model

F

r^2

β

ΔR^2

F

r^2

β

ΔR^2

Step 1:

1.22

1.15

Gender

0.03427

0.10819

0.04553

0.14711

Lifetime Alcohol Exposure

0.00733

−0.20394

0.01115

−0.20133

Lifetime Drug Use

0.05823

0.27354

0.03796

0.22086

Step 2:

1.58

0.0845 ϯ

2.18

0.1426 ϯ

S2 Number of Birthday Drinks

0.13793

0.45664 ϯ

0.14982

0.47591 ϯ

Note. While all Region of Interest (ROI) and Diffusion Tenor Imaging (DTI) scalar (i.e., AD, FA, MD, and RD) combinations were evaluated, only the ROIs/scalars that had significant predictors in at least one of the four models are provided in the current table, regardless of overall model significance. ΔR^2 is the change in model fit when the given variable (Step 2) is added to a model already including gender, total lifetime alcohol exposure, and lifetime drug use (Step 1). S2 = Session 2. FA = fractional anisotropy, AD = axial diffusivity, MD = mean diffusivity, RD = radial diffusivity. F = F-value; β = standardized parameter estimate. The degrees of freedom were (3, 33) for Step 1 and (4, 28) for Step 2. For the gender variable, 0 = female. Bold = significant at p < .05 level.

^ϯValues that do not remain significant after set-wise Bonferroni correction (p ≤ 0.003125).