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. 2020 May 27;12:3981–3993. doi: 10.2147/CMAR.S252232

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© 2020 Song et al.

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Cells after transduction with KLHL22 shRNA or +KLHL22 lentivirus to regulate the expression of EMT markers. We performed a Western blotting assessment of E-cadherin, N-cadherin, vimentin, Twist1 and Snail1 protein expression. (A, B) The results showed that the expression levels of N-cadherin, vimentin, Twist1 and Snail1 were increased and that E-cadherin expression was reduce when HCT116 and SW480 cells KLHL22 gene silenced by Lentivirus. (C) However, when KLHL22 protein was overexpressed in LOVO cells, the expression levels of N-cadherin, vimentin Twist1 and Snail1 decreased, and the expression levels of E-cadherin increased. GAPDH was used as the loading controls. (**p < 0.01 by Student’s t-test).