Table 4.
Genetic variations contributing to colistin resistance.
| Isolate | Colistin susceptibility | Category of resistance mechanism | mgrB | pmrB | phoP | phoQ | pmrC | arnB | ugd |
|---|---|---|---|---|---|---|---|---|---|
| CI103_10160/AOG30_10755a | CI103_03610/AOG30_18810 | CI103_16945/AOG30_17125 | CI103_16950/AOG30_17130 | CI103_18860/AOG30_18800 | CI103_01375/AOG30_01390 | CI103_08920 /AOG30_09695 | |||
| ATH7 | S | V53G (158T>Gb) | |||||||
| ATH8 | R | I | mgrB::N25ISKpn26-like | V53G (158T>G) | |||||
| ATH15 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | N253T (758A>C) | |||||
| ATH16 | R | II | mgrB::N25ISKpn26-like | V53G (158T>G) | N253T (758A>C), D438H (1312G>C) | ||||
| ATH17 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | N253T (758A>C) | |||||
| ATH18 | R | II | mgrB::N25ISKpn26-like | V53G (158T>G) | N253T (758A>C), T439P (1315A>C) | ||||
| ATH21 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | N253T (758A>C) | R306S (916C>A) | E176Del (527_529delAAG) | |||
| ATH22 | R | II | mgrB::N25ISKpn26-like | V53G (158T>G) | N253P (757_758delAAinsCC) | ||||
| ATH23 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | V446G (1337T>G) | |||||
| ATH24 | R | I | mgrB::N25ISKpn26-like | V53G (158T>G) | |||||
| ATH25 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | L239P (716T>C) | |||||
| ATH26 | R | I | mgrB::N25ISKpn26-like | V53G (158T>G) | |||||
| ATH30 | S | mgrB::N25ISKpn26-like | V53G (158T>G) | V446G (1337T>G) | |||||
| ATH29 | R | I | mgrB::N25ISKpn26-like | V53G (158T>G) | |||||
| ATH9 | S | mgrB::N25ISKpn26-like | T140P (418A>C) | −38G>T | G39S (115G>A) | E307Stop (919G>T) | −58A>G | ||
| ATH10 | R | I | mgrB::N25ISKpn26-like | T140P (418A>C) |
−38G>T | E307Stop (919G>T) | −58A>G |
a
Loci in AUSMDU0008079/TGH13 genome.
b
Nucleotide variations.