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. 2020 May 26;8:424. doi: 10.3389/fbioe.2020.00424

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Copyright © 2020 Guryanov, Naumenko, Akhatova, Lazzara, Cavallaro, Nigamatzyanova and Fakhrullin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genotoxic effects of prodigiosin-HNTs (p-HNTs) were evaluated using Comet Assay. Upper image – representative fields of view (fluorescent microscopy) with characteristic undamaged nucleoids and comets in each variant of experiment (specified in figure). The histogram shows the ratio of the DNA percentage in the tail and head of the comets. The semi-automated image analysis system Comet Score was used to evaluate 100 comets per sample.