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. 2020 May 26;11:767. doi: 10.3389/fphar.2020.00767

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Copyright © 2020 Jiang, Wang, Luo, Lin, Feng, Yan, Shi, Zhang, Gu, Cui, Wang, Wang, Zhang and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyporus polysaccharide (PPS) alleviates bleomycin (BLM)-induced pulmonary fibrosis. (A) Representative photographs of whole lungs (left lung) obtained on day 21 after treatment. (B) Lung fibrosis in mice, assessed by hematoxylin and eosin (HE) staining and Masson's trichrome blue staining (C) (Scale bars, 100 μm). Photomicrographs are representative of at least five independent experiments. (D) Semiquantitative analysis of pulmonary fibrosis in mice, using the Ashcroft score. Scatter plots show the mean± SD (n = 5, per group). (E) Wight changes in different group (n = 5, per group). (F) Representative Western blot results for Fibronectin, Collagen 1, and Collagen 3 expression in lung tissue. Scatter plots show the mean ± SD quantitative results obtained using three independent studies. ^## = p < 0.01 versus control (Con); * = p < 0.05, ** = p < 0.01 versus BLM group.