Table 2.
Function of the bone ECM in MSCs.
| Bone ECM | Functions in MSCs | Mechanism | Cell/Mice model | Reference |
|---|---|---|---|---|
| Biglycan | BMSCs production and proliferation (+) | Regulate amounts of collagen type I and response to TGF-β | Biglycan−/− mice | (Chen et al., 2002) |
| Biglycan and Decorin | BMSCs survival and growth (+) | Regulate response to TGF-β | Biglycan Decorin DKO mice | (Bi et al., 2005) |
| TSP1 | MSC osteogenesis (−); MSC proliferation (+) |
Latent TGF-β activation | MSCs | (Bailey Dubose et al., 2012; Belotti et al., 2016) |
| TSP2 | MSC number and proliferation ability (−); MSC osteogenesis (+) | Regulate collagen fibrillogenesis | TSP2−/− mice | (Hankenson et al., 2000; Alford et al., 2013) |
| OPN | MSC proliferation capacity (+); MSCs migration (+) | Regulate F-actin cytoskeleton and chromatin structure | MSCs | (Carvalho et al., 2019a; Liu et al., 2019) |
| OCN | MSC osteogenesis (+) | Increase extracellular calcium and ALP | MSCs | (Carvalho et al., 2019a) |
| DMP1 | MSCs pluripotency (+); MSC osteogenesis (−) | – | Prx1-cre; DMP1fl/fl mice | (Zhang S.F. et al., 2018) |
DKO, double knockout.