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. 2020 May 26;14:143. doi: 10.3389/fncel.2020.00143

Figure 6.

Figure 6

EpoB increases migration of SCs by promoting autophagy. Representative western blotting (A) and data analysis of LC3 and p62 in each group (B). TEM analysis showing the presence of autophagosomes in SCs from the control (C,G), EpoB (D,H), 3-MA (E,I), and EpoB+3-MA (F,J) groups. White arrowheads indicate normal endoplasmic reticula; black arrowheads indicate double-membraned autophagosomes. (K) Quantification of the total number of autophagosomes in each group. Transwell analysis of migratory cells in the control (M), EpoB (N), 3-MA (O), and EpoB+3-MA (P) groups at 24 h after treatment. (L) Quantification of the total number of migratory cells in each group. Scale bars: (C–F) 4 μm; (G–J) 1 μm. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the control group; #P < 0.05 and ###P < 0.001 compared to the EpoB group. Abbreviations: EpoB, epothilone B; 3-MA, 3-methyladenine; SCs, Schwann cells; TEM, transmission electron microscopy.