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. 2020 May 26;11:763. doi: 10.3389/fphar.2020.00763

Table 4.

Subgroup meta-analysis results of follow-up period.

Outcomes Subgroups WMD (95% Cl) P Test for heterogeneity Analysis model Sample size Number of study
I2 (%) P Combination treatment Tamsulosin monotherapy
TIPSS ≤3 months 1.680 (2.729,0.630) 0.002 93.80% 0.000 R 1,777 1,810 15
>3 months −1.330 (−3.485, 0.825) 0.227 85.10% 0.009 R 93 87 2
SIPSS ≤3 months −0.276 (−0.625, 0.073) 0.121 73.50% 0.000 R 998 995 7
VIPSS ≤3 months −0.311 (−0.655, 0.033) 0.076 43.40% 0.048 F 1,051 1,048 8
QMAX ≤3 months 1.799 (0.719, 2.878) 0.001 94.20% 0.000 R 959 894 11
>3 months 1.973 (3.571, 0.376) 0.015 0.00% 0.524 F 93 87 2
OABSS ≤3 months 1.202 (2.044,0.361) 0.005 95.60% 0.000 R 613 647 7
QOL ≤3 months 0.382 (0.746,0.018) 0.039 94.50% 0.000 R 903 905 9
PVR ≤3 months 3.138 (−2.011, 8.286) 0.232 78.30% 0.000 R 964 961 7
>3 months 9.439 (18.161,0.717) 0.034 77.30% 0.036 R 93 87 2
Urgency episodes per 24 h ≤3 months 0.208 (0.086, 0.330) 0.001 23.20% 0.237 F 1,093 996 4
>3 months −0.094 (−0.305, 0.116) 0.378 0.00% 0.351 F 93 87 2
Micturitions per 24 h ≤3 months 0.145 (−0.156, 0.445) 0.345 56.30% 0.019 R 1,006 996 5
PSA ≤3 months 0.192 (0.132, 0.253) <0.001 0.00% 0.596 F 667 689 6

WMD, Weighted mean difference; CI, confidence interval; R, random effects model; F, fixed effects model; TIPSS, Total International Prostate Symptom Score; SIPSS, Storage International Prostate Symptom Score; VIPSS, Voiding International Prostate Symptom Score; QOL, Quality of life; QMAX, Maximal urinary flow rate; PVR, Post void residual volume; PSA, Prostate specific antigen; OABSS, Overactive bladder symptom score.

Bold values meant P-value < 0.05.