Table 3.

Ontology enrichment analysis of genes differentially up-regulated in RA.

Annotation Cluster 1	Enrichment Score: 7.07	Genes Count (%)	Significance P Value	Fold Enrichment	FDR
Category	Term
GOTERM_CC_ALL	secretory granule	16 (10.88)	3.35 × 10−11	10.40	4.21 × 10−8
GOTERM_CC_ALL	Vesicle	23 (15.65)	4.72 × 10−8	4.02	5.93 × 10−5
GOTERM_CC_ALL	cytoplasmic vesicle	22 (14.97)	1.06 × 10−7	4.01	1.33 × 10−4
GOTERM_CC_ALL	cytoplasmic membrane-bounded vesicle	18 (12.25)	4.15 × 10−6	3.83	5.22 × 10−3
GOTERM_CC_ALL	membrane-bounded vesicle	18 (12.25)	6.36 × 10−6	3.71	7.99 × 10−3
Annotation Cluster 2	Enrichment Score: 6.74
GOTERM_BP_ALL	Hemostasis	10 (7.48)	3.55 × 10−8	11.50	5.95 × 10−5
GOTERM_BP_ALL	Coagulation	10 (6.80)	2.68 × 10−7	11.07	4.48 × 10−4
GOTERM_BP_ALL	blood coagulation	11 (6.80)	2.68 × 10−7	11.07	4.48 × 10−4
GOTERM_BP_ALL	regulation of body fluid levels	10 (7.48)	4.44 × 10−7	8.81	7.43 × 10−4
Annotation Cluster 3	Enrichment Score: 5.50
GOTERM_BP_ALL	response to other organism	15 (10.20)	2.51 × 10−7	5.84	4.19 × 10−4
GOTERM_BP_ALL	response to biotic stimulus	16 (10.88)	1.35 × 10−6	4.71	2.26 × 10−3
Annotation Cluster 4	Enrichment Score: 4.37
GOTERM_BP_ALL	Taxis	10 (6.80)	1.15 × 10−5	7.06	1.93 × 10−2
GOTERM_BP_ALL	Chemotaxis	10 (6.80)	1.15 × 10−5	7.06	1.93 × 10−2
GOTERM_BP_ALL	locomotory behaviour	12 (8.16)	2.93 × 10−5	4.95	4.90 × 10−2
Annotation Cluster 5	Enrichment Score: 3.79
GOTERM_MF_ALL	P-P-bond-hydrolysis-driven transmembrane transporter activity	9 (6.12)	1.07 × 10−5	8.46	1.48 × 10−2
GOTERM_MF_ALL	primary active transmembrane transporter activity	9 (6.12)	1.07 × 10−5	8.46	1.48 × 10−2
Annotation Cluster 6	Enrichment Score: 3.63
GOTERM_BP_ALL	positive regulation of protein kinase activity	11 (7.48)	2.69 × 10−5	5.57	4.49 × 10−2