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. 2020 Jun 1;10(6):65. doi: 10.1038/s41408-020-0331-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Human T cells (40,000 cells/well) were cultured with CFSE labeled AML KG-1 (a, b) or MM H929 cell lines (c, d) 2:1 ratio in the presence or absence of stromal cells (HS-5, HS-27a, primary MSC, or CD105⁺ endothelial cells; 20,000 cells per well). Varying concentrations of CD123xCD3 (a, b) or BCMAxCD3 (c, d) were added to cultures for 48 h. The percentage of dead CFSE⁺ cells was quantitated by flow cytometry. Dose titration graphs on the left (a, c) are shown with means ± standard deviation (SD). Scatter plots on the right (b, d) show data for the highest concentration of the bispecific antibody (median with range). Data are representative of three or more experiments. ∗∗p < 0.005, ∗∗∗p < 0.0005; ∗∗∗∗p < 0.0001; n.s. not statistically significant.