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. 2020 Jun 1;11:2695. doi: 10.1038/s41467-020-16537-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of all the significant interactions between baited promoters and H3K4me1/H3K27ac positive enhancers. b Histogram showing the distance between interacting promoter-fragments and enhancer-fragments. The median distance is 93.8 kb. c Histogram showing the number of enhancer interactions pr. promoter. The median number of interactions is 4. d Promoters captured by the Promoter Capture Hi-C were divided into three groups; promoters connected to enhancers that did not change H3K27ac in response to palmitate or TNFα treatment (“None”), and promoters connected to enhancers that either gained H3K27ac (“Up”) or lost H3K27ac (“Down”). e–j Empirical cumulative distribution function (EDCF) plots of gene expression changes (RNA-seq logFC values) in the “Up” versus the “None” group for palmitate (e) or TNFα treatment (f), and the “Down” versus the “None” group for palmitate (g) or TNFα treatment (h). X-axis is the RNA-seq logFC, y-axis is the fraction of genes with this logFC or less. Differences between empirical cumulative distribution functions were tested using a Kolmogorov-Smirnov test (KS-test).