Table 4.
Representative rules for classifying tumor cells from different tissues.
| Index | Feature ranking method | Rule learning algorithm |
Rule conditions |
Classified tissues |
Marker genes |
|---|---|---|---|---|---|
| Rule 1 | mRMR | RIPPER | (cg03977657 ≤ 0.099) and (cg01149192 ≤ 0.666) and (cg25593954 ≥ 0.757) | Aerodigestive tract | LAMB3, MGAT1, SPOP |
| Rule 2 | mRMR | RIPPER | (cg00983904 ≥ 0.833) and (cg24393316 ≤ 0.090) and (cg04976330 ≥ 0.777) | Lung | IFFO1, FOXE1, PUM1 |
| Rule 3 | MCFS | RIPPER | (cg22609576 ≥ 0.084) and (cg00879790 ≤ 0.134) | Digestive system | TRIM15, SPG20 |
| Rule 4 | MCFS | RIPPER | (cg20783697 ≤ 0.300) | Blood | BZRAP1 |
| Rule 5 | mRMR | PART | (cg22203219 ≤ 0.460) and (cg16419724 > 0.408) and (cg08454824 > 0.683) and (cg13466284 > 0.577) and (cg16798247 ≤ 0.754) and (cg00989853 > 0.900) | Nervous system | IFFO1, MARVED2, ERICH1, SFN, ELMO1, IRF6 |
| Rule 6 | mRMR | PART | (cg20783697 ≤ 0.698) and (cg01951274 ≤ 0.130) | Blood | BZRAP1, MIR142 |
| Rule 7 | MCFS | PART | (cg02505827 ≤ 0.184) and (cg19519643 ≤ 0.785) and (cg00112091 > 0.118) and (cg05607401 ≤ 0.864) | Urogenital system | TEAD1, GMFG, MARVELD2 |
| Rule 8 | MCFS | PART | (cg02505827 ≤ 0.150) and (cg23229016 ≤ 0.645) | Skin | MARVELD2, RPS6KA1 |