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. 2020 Jun 1;11(6):409. doi: 10.1038/s41419-020-2606-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Mice were administered with mCherry-labeled iPSC-MSC-sEV, and whole-body imaging was performed to detect the distribution of sEV at the indicated time points. b Total lung cells were isolated and MFI of mCherry in macrophages was analyzed by means of flow cytometry. Pulmonary macrophages significantly uptook MSC-EVs at 4 h post-administration. *P < 0.05. MFI mean fluorescence intensity, ns not significant.