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. 2020 Jun 1;11(6):409. doi: 10.1038/s41419-020-2606-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Raw 264.7 macrophages were stimulated with IL-4 for 48 h for polarization of M2 macrophages (a), and were treated with three types of MSC-sEV. The mRNA levels of Arg1, Fizz1, and Ym1 were determined by qRT-PCR (b). c Venn diagram for the numbers of protein identified by iPSC-MSC-sEV, BM-MSC-sEV, and G-MSC-sEV. d–f GO analysis of the protein co-expressed by iPSC-MSC-sEV, BM-MSC-sEV, and G-MSC-sEV. ***P < 0.001 and ****P < 0.0001. BM-MSCs bone marrow-derived mesenchymal stromal cells, G-MSCs gingiva-derived mesenchymal stromal cells, iPSC-MSCs induced pluripotent stem cell-derived mesenchymal stromal cells, sEV small extracellular vesicles.