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. 2020 Jun 1;10:8858. doi: 10.1038/s41598-020-65649-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Propofol affects response to trastuzumab. Parental (A) or Trastuzumab-resistant (Tr-R) (B) SKBR3 cells were treated with increasing doses of trastuzumab as indicated on X-axis in the presence of either DMSO vehicle or 5 μg/ml propofol for 96 h. Cell viability was calculated by CCK8 assay. The number of viable cells in 0 μg/ml trastuzumab treated vehicle group were regarded as 100% and the ‘relative’ percentage in other groups was calculated. ^#p < 0.01, compared to vehicle.