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. 2020 Jun 1;10:8863. doi: 10.1038/s41598-020-65928-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of PRP3 is increased in cSCC cells and tissues. (A) PRP3 mRNA expression in cSCC cells compared with benign epidermal keratinocyte cells. (B) PRP3 protein expression in cSCC cells compared with benign epidermal keratinocyte cells. (C) Relative protein expression of PRP3 in cSCC cells versus benign epidermal keratinocyte cells. (D) PRP3 protein expression in cSCC tissues was examined via western-blotting. (E) PRP3 protein expression in normal human skin, AK, cSCCs in situ and sporadic cSCCs tissues were explored via IHC. (F) High PRP3 expression is associated with poor prognosis in cSCCs patients. ^*P < 0.05, ^**P < 0.01. PRP3, pre-mRNA processing factor 3.