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. 2020 Jun 1;11:2699. doi: 10.1038/s41467-020-16526-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Force-frequency relation of WT, Compound-Het and S6366I Hom EDL muscle. Inset shows maximal force (200 Hz stimulation rate). Force is reduced in Compound-Het and S6366I Hom mice. (Force expressed as specific force: force per unit area of muscle, mN/mm²). *p = 0.013, **p = 0.007. b Relative force-frequency shows steeper force rise in Compound-Het mice. c Frequency for 50% force (F_50%) is reduced in Compound-Het mice. **p = 0.0012. d Hill coefficient is increased in Compound-Het mice. ****p < 0.0001. e Time to 1/2 maximal force of 200 Hz tetanus is reduced in Compound-Het mice. ***p = 0.0005. f Time to 1/2 relaxation of 200 Hz tetanus is increased in Compound-Het mice and S6366I Hom mice. **p = 0.002, ***p = 0.0008 and ****p < 0.0001. a–f: n(WT) = 20 mice; n(Compound-Het) = 11 mice; n(S6366I Hom) = 11 mice. Bar values are mean ± SEM. a, b Non-linear least squares fit to Hill curve with as null hypothesis that one curve fits all data sets. Test (Sum-of-squares F-test) reveals that the null hypothesis is rejected in each panel (p ≤ 0.0001, F (DFn, DFd) 9.633 (8,408)). a inset and c–f: ordinary one-way ANOVA without matching or paring. A posthoc multiple testing comparison with multiple testing correction (Tukey) was performed. Source data are provided as a Source Data file.