Table 1.
Protein levels of cytokine, chemokine, and growth factors in the hippocampus at PND 51–55.
| Female (pg/ml ± s.d.) | Male (pg/ml ± s.d.) | ||||
|---|---|---|---|---|---|
| Analyte | Filtered Air | TRAP | Filtered Air | TRAP | Result |
| IL-1β | 24.07 ± 5.94 | 30.02 ± 6.14 | 26.54 ± 8.40 | 23.33 ± 5.94 | n.s. |
| IL-18 | 260.29 ± 13.81 | 301.76 ± 27.03 | 288.49 ± 87.90 | 260.58 ± 30.58 | n.s. |
| IL-1ɑ | 48.40 ± 8.20 | 51.93 ± 8.12 | 47.96 ± 5.85 | 44.82 ± 1.83 | n.s. |
| TNFɑ | 607.67 ± 123.70 | 665.84 ± 64.74 | 788.43 ± 742.93 | 616.39 ± 162.69 | n.s. |
| IL-6 | 1396.57 ± 124.81 | 1496.70 ± 113.50 | 1329.15 ± 65.24 | 1280.32 ± 72.62 | p = 0.003; Female > Male |
| IL-12 (p70) | 541.97 ± 88.58 | 605.44 ± 79.65 | 564.53 ± 47.95 | 536.06 ± 40.39 | n.s. |
| IL-17 | 116.80 ± 17.78 | 129.70 ± 12.87 | 120.68 ± 7.55 | 114.14 ± 5.02 | n.s. |
| IL-7 | 196.07 ± 8.90 | 217.92 ± 21.67 | 195.50 ± 27.22 | 189.73 ± 32.60 | n.s. |
| IL-2 | 1742.63 ± 229.40 | 1746.21 ± 255.39 | 1894.78 ± 508.37 | 1685.35 ± 473.38 | n.s. |
| IFNɣ | 8673.11 ± 1537.55 | 10204.31 ± 1875.28 | 9059.99 ± 1182.41 | 8243.57 ± 771.17 | n.s. |
| IL-4 | 54.55 ± 7.35 | 59.55 ± 7.45 | 54.37 ± 6.19 | 53.99 ± 6.55 | n.s. |
| IL-5 | 167.70 ± 17.42 | 180.06 ± 17.72 | 171.23 ± 9.62 | 163.38 ± 5.10 | n.s. |
| IL-10 | 408.32 ± 70.37 | 494.47 ± 29.87 | 419.98 ± 46.49 | 382.89 ± 36.07 | p = 0.014; TRAP Female > FA Female |
| IL-13 | 172.12 ± 26.80 | 190.18 ± 32.09 | 178.58 ± 21.29 | 166.68 ± 22.92 | n.s. |
| G-CSF | 22.38 ± 3.71 | 26.56 ± 2.87 | 20.77 ± 2.46 | 20.90 ± 2.16 | p = 0.008; Female > Male |
| GM-CSF | 141.74 ± 7.85 | 153.83 ± 14.97 | 138.42 ± 8.88 | 136.08 ± 15.87 | n.s. |
| M-CSF | 11.23 ± 2.03 | 12.78 ± 2.30 | 11.76 ± 1.65 | 10.61 ± 0.58 | n.s. |
| CXCL1 | 55.27 ± 7.42 | 60.91 ± 6.42 | 59.48 ± 3.53 | 53.71 ± 2.97 | n.s. |
| CCL3 | 20.36 ± 4.07 | 22.11 ± 3.06 | 21.01 ± 2.19 | 18.98 ± 1.05 | n.s. |
| CCL20 | 9.28 ± 1.48 | 10.33 ± 1.30 | 9.31 ± 0.79 | 8.92 ± 0.62 | n.s. |
| CCL5 | 59.28 ± 7.69 | 64.36 ± 6.69 | 62.81 ± 5.06 | 58.89 ± 3.47 | n.s. |
| CCL2 | 153.58 ± 12.61 | 165.91 ± 13.02 | 159.85 ± 17.56 | 145.18 ± 16.19 | p = 0.046; interaction sex and exposure |
| VEGF | 316.99 ± 51.37 | 341.82 ± 40.88 | 333.32 ± 25.45 | 310.21 ± 20.51 | n.s. |
Data represent the mean ± SD (n = 5–6 animals/group with two technical replicates/animal). Significant main effects of sex, exposure, or interactions between sex and exposure were determined by two-way ANOVA with post hoc Sidak’s test.