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. 2020 Jun 1;11(6):411. doi: 10.1038/s41419-020-2615-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Protein levels of the principal TrkB downstream signaling proteins including a PLCγ, b pPLCγ, c Akt, and d pAkt and iNOS Histograms represent the protein expression expressed as the percentage of TrkB^f/f-GFP-Veh. Representative immunoblots are shown. All data are shown as the mean ± SEM (TrkB^f/f-GFP-Veh (n = 15); TrkB^f/f-GFP-Pilo (n = 10); TrkB^f/f-GFAP-Cre-Pilo (n = 8); TrkB^f/f-CaMKII-Cre-Pilo (n = 12)). Data were analyzed by one-way ANOVA followed by Tukey’s test. *p < 0.05 compared with TrkB^f/f-GFP-veh. g Representative images showing Fluoro-Jade-positive cells (FJ+) in the three experimental conditions in CA1, CA3, and CA4. Scale bar: 100 μm. The histogram represents the number of FJ+ cells expressed as the percentage of the number of positive cells found in the CA1 of TrkB^f/f-GFP-Pilo. All data are shown as mean ± SEM (TrkB^f/f-GFP-Pilo (n = 13); TrkB^f/f-CaMKII-Cre-Pilo (n = 4); TrkB^f/f-GFAP-Cre-Pilo (n = 8)). Data were analyzed by one-way ANOVA followed by Tukey’s test. *p < 0.05 compared with TrkB^f/f-GFP-Pilo.